논문 국내 국제전문학술지(SCI급) Isolation of 6,6’-bieckol from Grateloupia elliptica and its antioxidative and anti-cholinesterase activity
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2017-03
- 저자명 Lee B.H.공동(교신),Lee S.Y.,Choi B.W.
- 학술지명 Ocean and Polar Research
- 발행처명 Korea Ocean Research and Development Institute
- 발행국가 국내
- 논문언어 한국어
홈페이지논문 초록 (Abstract)
During the search for anticholinesterase compounds from marine organisms, we were able to isolate 6,6’-bieckol from a red alga, Grateloupia elliptica. This compound showed moderate acetylcholinesterase (AChE) inhibitory activity in a micromole range (IC50 44.5 μM). However, for butyrylcholinesterase (BuChE), a new target for the treatment of Alzheimer’s disease (AD), it showed particularly potent inhibitory activity (IC50 27.4 μM), which is more potent compared to AChE. It also inhibits BACE-1, a new target for reducing the generation of β-amyloid.