논문 국내 국내일반학술지 오수유의 CHOLINESTERASE 저해활성 성분
- 학술지 구분 국내일반학술지
- 게재년월 2012-06
- 저자명 유시용,이지영,차미란,이봉호공동(참여),최춘환,김영섭
- 학술지명 생약학회지
- 발행처명 한국생약학회
- 발행국가 국내
- 논문언어 한국어
홈페이지논문 초록 (Abstract)
The MeOH extract of Evodiae Fructus exhibited a significant inhibition on the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), in a dose dependent manner, respectively. The extensive bioactivity-guided fractionation process with the MeOH extract finally isolated four compounds, as rutaecarpine (1), evodiamine (2), limonin (3) and dehydroevodiamine (4). Among them, compound 2 exhibited specific inhibitory activity on BChE with the IC50 values 1.7 ?g/ml, whereas compound 4 showed the potent inhibition upon both AChE and BChE.