논문 국내 국내전문학술지(KCI급) ANTI-HYPERLIPIDEMIC EFFECT OF POLYPHENOL EXTRACT (SEAPOLYNOLTM) AND DIECKOL ISOLATED FROM ECKLONIA CAVA IN IN VIVO AND IN VITRO MODELS
- 학술지 구분 국내전문학술지(KCI급)
- 게재년월 2012-03
- 저자명 김성호,유영춘,조영래,이봉호공동(참여),여아름,이정림,태인환,박석래,신현철
- 학술지명 PREVENTIVE NUTRITION AND FOOD SCIENCE
- 발행처명 한국식품영양과학회
- 발행국가 국내
- 논문언어 외국어
홈페이지논문 초록 (Abstract)
The inhibitory effect of polyphenol extracts (Seapolynol™, SPN) of the marine brown algae Ecklonia cava and dieckol, a major component of SPN, on hyperlipidemia was investigated in ICR mice fed a high-fat diet (HFD) for five weeks. For analysis of the anti-hyperlipidemic effects of SPN and dieckol, these two agents were given orally on a daily basis to HFD-fed mice for four weeks, starting one week after the beginning of HFD feeding. Groups administered with SPN as well as dieckol showed lower body weight gains than the HFD only group. Administration of SPN and dieckol also resulted in a significant reduction of the level of total cholesterol (TCHO), triglyceride (TG), and low-density lipoprotein (LDL) cholesterol in the serum of HFD-fed mice. In Oil Red O staining using 3T3-L1 preadipocytes, it was shown that both SPN and dieckol markedly inhibited lipid accumulation of 3T3-L1 cells. Furthermore, SPN and dieckol (50 μg/mL) significantly inhibited 3-hydroxyl-methyl glutaryl coenzyme A (HMGCoA) reductase activity in vitro. Taken together, these results suggest that polyphenols of Ecklonia cava (SPN) and dieckol reduce body weight gain and fat accumulation in HFD-induced obese mice, and that their hypolipidemic effect is related to the inhibition of adipogenesis of adipocytes and HMGCoA reductase activity.