논문 국내 국내전문학술지(KCI급) KYUNG BOK LEE,BONG HO LEE공동(참여),HEE YOUN CHEE,EUN-JUNG KIM,SANG-MUK OH,CHANG GYO PARK,JOO HEE KANG
- 학술지 구분 국내전문학술지(KCI급)
- 게재년월 2011-06
- 저자명 DIECKOL INHIBITS 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED SK-HEP1 HUMAN HEPATOMA CELL MOTILITY THROUGH SUPPRESSION OF MATRIX METALLOPROTEINASE-9 ACTIVITY
- 학술지명 JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
- 발행처명 KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
- 발행국가 국내
- 논문언어 한국어
홈페이지논문 초록 (Abstract)
Dieckol, a polyphenol compound extracted from Brown algae, Ecklonia cava, is known to have anti-inflammatory and anti-tumorigenic activities. However, the underlying molecular mechanism by which dieckol regulates cancer cell growth and proliferation remains elusive. Here we report that dieckol extracted from Ecklonia cava inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced human hepatocellular carcinoma SK-Hep1 cell motility, and that dieckol decreased extracellular signal-regulated kinases 1/2 and c-Jun N-terminal kinases (JNKs) activities, but not p38 Mitogen-Activated Protein Kinase (MAPK), in dose-dependent manner. Dieckol reduced TPA-induced activator protein-1 transcriptional activity. TPA-induced matrix metalloproteinase-9 (MMP-9) activity was greatly reduced in SK-Hep1 cells by treatment of dieckol. These findings suggest that dieckol functions as a potent inhibitor for tumor promoter-mediated MAPK signaling pathways leading to Activator Protein 1 (AP-1) and MMP-9 activation thereby regulates cancer cell motility.