논문 국내 국제전문학술지(SCI급) ECKLONIA CAVA POLYPHENOLS
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2011-01
- 저자명 YONGJU PARK,BONG HO LEE공동(참여),SEONG HO KIM,HYE JEONG HWANG,HYEON-CHEOL SHIN
- 학술지명 PHYTOTHERAPY RESEARCH
- 발행처명 Wiley
- 발행국가 국내
- 논문언어 한국어
홈페이지논문 초록 (Abstract)
Obesity is considered to be a metaflammatory condition. Ecklonia cava, brown algae rich in polyphenols, has shown strong antioxidant activity in vitro. This study investigated the effect of E. cava polyphenol extract (ECPE) on the regulation of fat metabolism, inflammation, and the antioxidant defense system in high fat diet-induced obese mice. After obesity was induced by a high-fat diet (HFD), the mice were administered ECPE by gavage for 5 days/12 weeks. ECPE supplementation reduced body weight gain, adipose tissue mass, plasma lipid profiles, hepatic fat deposition, insulin resistance, and the plasma leptin/adiponectin ratio derived from HFD-induced obesity. Moreover, ECPE supplementation selectively ameliorated hepatic protein levels associated with lipogenesis, inflammation, and the antioxidant defense system as well as activation of AMPK and SIRT1. Collectively, ECPE supplement might have potential antiobesity effects via regulation of AMPK and SIRT1 in HFD-induced obesity.