논문 국내 국내전문학술지(KCI급) New cholinesterase inhibitor, lipoic acid-nitrone derivatives
- 학술지 구분 국내전문학술지(KCI급)
- 게재년월 2007-02
- 저자명 남강희,최병욱,이봉호공동(참여),박정호,서윤미,성민태
- 학술지명 BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- 발행처명 KOREAN CHEMICAL SOC
- 발행국가 국내
- 논문언어 한국어
홈페이지논문 초록 (Abstract)
Lipoic acid (LA) is a multifunctional antioxidant against a variety of ROS. Nitrone acts as free radical spin trap and exhibits neuroprotective activity. Thus, LA-nitrone derivatives (6, 7, 8, and 9) were synthesized and screened as an antioxidant and inhibitors for cholinesterases. Even though the antioxidant effect of LA-nitrone derivatives was not improved, they turned out to be effective inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in mM range.