논문 국내 국내일반학술지 The Radical Scavenging Effect of Stilbene Glucoside from Polygonum multiflorum
- 학술지 구분 국내일반학술지
- 게재년월 2002-05
- 저자명 이봉호공동(교신)
- 학술지명 Archives of Pharmacal Research
- 발행처명 대한약학회
- 발행국가 국내
- 논문언어 한국어
홈페이지논문 초록 (Abstract)
The extract of the root of Polygonum multiflorum exhibited a significant antioxidant activity assessed by the DPPH radical scavenging activity in vitro. The bioassay-guided fractionation of the extract yielded a stilbene glucoside, (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucopyranoside (1) as an active constituent responsible for the antioxidant property. Compound 1 demonstrated a moderate DPPH radical scavenging activity (IC50, 40 microM), while the corresponding deglucosylated stilbene 2 exhibited a much higher activity (IC50, 0.38 microM).