논문 해외 국제전문학술지(SCI급) MULTIFUNCTIONAL ACTIVITY OF POLYPHENOLIC COMPOUNDS ASSOCIATED WITH A POTENTIAL FOR ALZHEIMER'S DISEASE THERAPY FROM ECKLONIA CAVA
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2015-04
- 저자명 B.W.CHOI,이봉호공동(교신),H.C.SHIN,H.S.LEE
- 학술지명 PHYTOTHERAPY RESEARCH
- 발행처명 JOHN WILEY & SONS LTD
- 발행국가 해외
- 논문언어 외국어
홈페이지논문 초록 (Abstract)
Five polyphenols were isolated and purified from a brown alga Ecklonia cava. These compounds showed diverse biological activities such as antioxidative, antiinflammatory, and enzyme inhibitory activities. This led us to investigate the potential of these compounds as Alzheimer's disease drugs. All of the compounds showed moderate acetylcholinesterase inhibitory activity in a micromolar range (IC50 from 16.0 to 96.3 μM). For butyrylcholinesterase, a new target for the treatment of Alzheimer's disease, phlorofucofuroeckol-A (PFF-A), showed a particularly potent inhibitory activity (IC50 0.95 μM), which is over 100-fold greater than for acetylcholinesterase. These compounds inhibited glycogen synthase kinase 3 beta, which is related to the formation of hyperphosphorylated tau and generation Aβ. Bieckol and PFF-A inhibited amyloid precursor protein biosynthesis. PFF-A also showed very strong β-secretase inhibitory activity with IC50 of submicromole. These results render these compounds as interesting potential drug candidates for Alzheimer's disease.