논문 해외 국제전문학술지(SCI급) ISOLATION OF DIACYL GLYCEROL ACYL TRANSFERASE (DGAT) INHIBITORS FROM PACHYDICTYON CORIACEUM
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2011-07
- 저자명 BYOUNG WOOK CHOI,BONG HO LEE공동(교신),HYUN SUN LEE,KYUNG BOK LEE
- 학술지명 PHYTOTHERAPY RESEARCH
- 발행처명 WILEY-BLACKWELL
- 발행국가 해외
- 논문언어 외국어
홈페이지논문 초록 (Abstract)
The pharmacological inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) has emerged as a target for the treatment of obesity and type 2 diabetes. Chromatographic analysis of the brown alga, Pachydictyon coriaceum, led to the isolation of diterpene dictyol E and hydroxyisocrenulatin. Pharmacological assay of these compounds demonstrated DGAT inhibitory activity with IC₅₀ values of 46.0 μM and 23.3 μM, respectively.