논문 해외 국제전문학술지(SCI급) Artificial Differentiation of Hippocampal Neurons by Electrical Stimulation on Graphene Electrode
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2019-12
- 저자명 임준묵공동(참여),송광섭,임기무,박우환,김대훈,홍기오
- 학술지명 JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- 발행처명 AMER SCIENTIFIC PUBLISHERS
- 발행국가 해외
- 논문언어 외국어
- 전체저자수 6
홈페이지논문 초록 (Abstract)
Electrical stimulation therapy is a promising method for treating neurological diseases. This method induces the activity and differentiation of nerve cells by the direct or indirect transmission of an electrical signal through biomedical electrodes. We demonstrated the efficacy of a graphene sheet as a bioelectrode to differentiate neurites from hippocampal neuron, through electrical stimulation. In order to the artificially induce the differentiation of hippocampal neurons, we directly transmitted electrical signals of square pulse through the graphene electrode to directly stimulate neurons cultured onto graphene surface. Compared to cell culture plates, the average length of differentiated neurites increased 111.1% on pristine graphene with electrical stimulation. And the average number of differentiated neurites on a single cell increased to 281.9% on oxygenated graphene with electrical stimulation. Electrical stimulation with graphene electrodes promoted the differentiation of neurites and activated the production of intercellular networks of hippocampal neurons.