논문 해외 국제전문학술지(SCI급) Photothermally Enhanced Molecular Delivery and Cellular Positioning on Patterned Plasmonic Interfaces
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2019-09
- 저자명 송지환
- 학술지명 ACS APPLIED MATERIALS INTERFACES
- 발행처명 AMER CHEMICAL SOC
- 발행국가 해외
- 논문언어 외국어
- 전체저자수 5
홈페이지논문 초록 (Abstract)
Photothermal conversion effect of plasmonic nanostructures is considered as a promising technique for cellular and molecular manipulations owing to controllability of local temperature. Therefore, this technique has been extensively applied to biological studies such as controlling cellular behavior, delivery of biologics, and biomolecular detection. Herein, we propose a novel method for directed cell positioning and photothermally modulated molecular delivery to the cells using patterned plasmonic interfaces. Plasmonic substrates with gold nanorods (GNRs) and cell adhesion molecules fabricated by microcontact printing are optimized for cellular positioning on designated patterns. Through the photothermal conversion effect of GNRs on the pattern, we further demonstrate on-demand, light-induced delivery of drug molecules to the target cells. We expect that this approach will provide a new way to study single cellular behaviors and enhance molecular delivery to the target cells.