논문 해외 국제전문학술지(SCI급) A study on the interfacial effect on cancer-cell invasion
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2011-04
- 저자명 송지환
- 학술지명 JOURNAL OF APPLIED PHYSICS
- 발행처명 AMER INST PHYSICS
- 발행국가 해외
- 논문언어 외국어
- 전체저자수 3
홈페이지논문 초록 (Abstract)
Cancer-cell invasion is a complex biological process involving cell migration through the extracellular matrix, which is driven by haptotaxis, and the interactions between cancer cells and the surrounding matrix. In this paper, a three-dimensional haptotaxis model that simulates the migration of a cancer cell population, including cell-cell adhesion and cell-matrix adhesion, is proposed. We employ a diffuse interface model that incorporates the mechanism of haptotaxis and the interface energy of cancer cells as well as that between cancer cells and the matrix. The semi-implicit Fourier spectral scheme is applied for high efficiency and numerical stability. The simulations systematically reveal the dynamics of cancer-cell migration and the effect of interface energy on the invasion of cancer cells. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3562183]