논문 해외 국제전문학술지(SCI급) Three-dimensional chemotaxis model for a crawling neutrophil
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2010-11
- 저자명 송지환
- 학술지명 PHYSICAL REVIEW E
- 발행처명 AMER PHYSICAL SOC
- 발행국가 해외
- 논문언어 외국어
- 전체저자수 2
홈페이지논문 초록 (Abstract)
Chemotactic cell migration is a fundamental phenomenon in complex biological processes. A rigorous understanding of the chemotactic mechanism of crawling cells has important implications for various medical and biological applications. In this paper, we propose a three-dimensional model of a single crawling cell to study its chemotaxis. A single-cell study of chemotaxis has an advantage over studies of a population of cells in that it provides a clearer observation of cell migration, which leads to more accurate assessments of chemotaxis. The model incorporates the surface energy of the cell and the interfacial interaction between the cell and substrate. The semi-implicit Fourier spectral method is applied to achieve high efficiency and numerical stability. The simulation results provide the kinetic and morphological traits of a crawling cell during chemotaxis.