논문 해외 국제전문학술지(SCI급) Bee Stinger-Like Wearable Electrospun Web Microneedles for Sustained CNS Drug Delivery
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2025-11
- 저자명 Ji-Hwan Ha, Yun‐Woo Lee, Soon Hyoung Hwang, Dahong Kim, Byung‐Ho Kang, Young Jo Song, Jihyun Won, Minsun Moon, Yoosik Yoon, Su A Park, Sohee Jeon, Wonku Kang, Jun‐Ho Jeong
- 학술지명 Advanced healthcare materials
- 발행국가 해외
- 논문언어 외국어
- 연구분야 공학 > 섬유공학
- 원문 링크 https://advanced.onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202501371
홈페이지논문 초록 (Abstract)
Microneedles (MNs) have emerged as a promising solution for pain-free and patient-friendly drug delivery. MNs provide therapeutic benefits with minimal invasiveness, thus reducing patient distress. However, although MNs have been proposed for the sustained delivery of drugs into the central nervous system (CNS), conventional rigid MNs lead to discomfort and fatigue during extended wear. In this study, wearable electrospun web MNs (EW-MNs) inspired by the mechanics of bee stingers are developed. Through the grounding of metal MNs and controlled formation of electrospun fibers, EW-MNs suitable for skin insertion and anchoring are fabricated. The penetration depth and drug diffusion performance are then evaluated. Sustained-release drug delivery along the fiber surface is validated using fluorescent dyes simulating a real therapeutic drug. Finally, the therapeutic mechanism and efficacy of EW-MNs loaded with CNS-targeted drugs, such as rivastigmine, are validated in guinea pig models, confirming their potential for continuous and effective CNS disease management. In vitro and in vivo evaluations showed a 2.5-fold increase in AUC and a fivefold expansion in drug diffusion area, demonstrating the efficacy of EW-MNs in sustained CNS drug delivery.